2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Chloride Channel

Chloride Channel

Cl− Channels

Chloride Channel

Related Products

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Chloride channels belong to a superfamily of ion channels that permit passive passage of anions, mainly chloride, across cell membrane. Chloride channels perform important roles in the regulation of cellular excitability, in transepithelial transport, cell volume regulation, and acidification of intracellular organelles. Chloride channels represent a group of potential drug targets.

The chloride channel protein (ClC) family comprises both chloride (Cl-) channels and chloride/proton (Cl-/H+) antiporters. In prokaryotes and eukaryotes, these proteins mediate the movement of Cl- ions across the membrane. In eukaryotes, ClC proteins play a role in the stabilization of membrane potential, epithelial ion transport, hippocampal neuroprotection, cardiac pacemaker activity and vesicular acidification.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-A0234
    Stepronin
    		Inhibitor 99.54%
    Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands.
    Stepronin
  • HY-168735
    SLC26A4-IN-1
    		Inhibitor 99.68%
    SLC26A4-IN-1 (compound 1a) is a pendrin/SLC26A4 inhibitor. pendrin is a Cl-/HCO3- exchanger.
    SLC26A4-IN-1
  • HY-B0493S1
    Niflumic acid-13C6
    		Inhibitor 99.8%
    Niflumic acid-13C6 is the 13C6 labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
    Niflumic acid-<sup>13</sup>C<sub>6</sub>
  • HY-118170
    T16A(inh)-C01
    		Inhibitor
    T16A(inh)-C01 is an inhibitor of TMEM16A (ANO1). T16A(inh)-C01 blocks chloride channel mediated by ANO1 with an IC50 of 8.4 μM, without interfering with calcium signaling.
    T16A(inh)-C01
  • HY-W009823
    Phenyl benzoate
    		Inhibitor 99.97%
    Phenyl benzoate is a benzoate ester obtained by the formal condensation of phenol with benzoic acid. Phenyl benzoate is a chloride transport blocker, inhibits Cl--dependent Glu accumulation into vesicles. Phenyl benzoate can be used as preservative in cosmetic products.
    Phenyl benzoate
  • HY-139587
    Umifoxolaner
    		Antagonist 99.97%
    umifoxolaner (ML-878) is a γ-aminobutyric acid (GABA) regulated chloride channels antagonist. Umifoxolaner is an anti-parasitic agent.
    Umifoxolaner
  • HY-B1371A
    Spiperone hydrochloride
    		Activator 99.10%
    Spiperone hydrochloride (Spiroperidol hydrochloride) is a selective dopamine D2 receptor (Ki values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D2, D3, D4, D1 and D5 receptors, respectively) and 5-HT2A/5-HT1A receptor (Kis of 1 nM/49 nM) antagonist. Spiperone hydrochloride is also a selective α1B-adrenoceptor antagonist. Spiperone hydrochloride activates calcium-activated chloride channel (CaCC). Antipsychotic and anti-inflammatory activities.
    Spiperone hydrochloride
  • HY-B1221S1
    Flufenamic acid-13C6
    		Inhibitor
    Flufenamic acid-13C6 is the 13C6 labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.
    Flufenamic acid-<sup>13</sup>C<sub>6</sub>
  • HY-106822
    Losigamone
    		99.94%
    Losigamone (AO-33) is an orally active antiepileptic compound. Losigamone blocks sodium channel. Losigamone stimulates the neuronal chloride channel and enhance chloride influx. Losigamone potentiates GABA-mediated responses and reduces epileptiform activity induced by chloride channel antagonists. Losigamone can be used for epilepsy research.
    Losigamone
  • HY-122732
    OADS
    		Inhibitor 98.25%
    OADS is a Chloride channel antiporter (ClC-ec1) inhibitor (IC50: 29 μM). OADS specifically inhibits the ClC-ec1 antiporter but not the ClC-1 channel. OADS can be used for research of osteoporosis and neurodegenerative and cardiovascular diseases.
    OADS
  • HY-B0493R
    Niflumic acid (Standard)
    		Inhibitor
    Niflumic acid (Standard) is the analytical standard of Niflumic acid. This product is intended for research and analytical applications. Niflumic acid is a calcium-activated chloride channel blocker and COX-2 inhibitor with the IC50 value of 100 nM. Niflumic acid induces apoptosis through caspase-8/Bid/Bax pathway in lung cancer cells. Niflumic acide exhibits anti-tumor activity by affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Niflumic acid has orally bioactivity. Niflumic acid acts on rheumatoid arthritis.
    Niflumic acid (Standard)
  • HY-P0173A
    Chlorotoxin
    		Inhibitor 98.54%
    Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity. Chlorotoxin is a chloride channel blocker.
    Chlorotoxin
  • HY-P0173
    Chlorotoxin(linear)
    		Inhibitor
    Chlorotoxin(linear) is a linear 36 amino-acid peptide which can be used in Chlorotoxin related research.
    Chlorotoxin(linear)
  • HY-106808
    Cerebrocrast
    		99.51%
    Cerebrocrast (IOS-1.1212) is a 1,4-dihydropyridine (DHP) derivative. Cerebrocrast has a high affinity for the membrane lipid bilayer and it can easily penetrate the blood-brain barrier and incorporate into the plasma and organelle membranes, including those of mitochondria. Cerebrocrast promotes the cotransport of H+ and Cl- in rat liver mitochondria. Cerebrocrast also exhibits neuroprotective and cognition enhancer properties.
    Cerebrocrast
  • HY-100244
    NS1652
    		Inhibitor 99.87%
    NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC50 of 1.6 μM in human and mouse red blood cells.
    NS1652
  • HY-109077
    Tigolaner
    		Modulator 98.53%
    Tigolaner (BAY-1272858) acts on γ-aminobutyric acid (GABA) and glutamate-gated chloride channels. Tigolaner has antiparasitic activity.
    Tigolaner
  • HY-N5101
    Kobusin
    		Modulator 99.93%
    Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel.
    Kobusin
  • HY-101329S
    Anthracene-9-carboxylic acid-d9
    		98.94%
    Anthracene-9-carboxylic acid-d9 is the deuterium labeled Anthracene-9-carboxylic acid. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells.
    Anthracene-9-carboxylic acid-d<sub>9</sub>
  • HY-P990337
    Anti-ANO1/TMEM16A Antibody
    		Inhibitor
    Anti-ANO1/TMEM16A Antibody is a CHO-expressed human antibody that targets ANO1/TMEM16A. The Anti-ANO1/TMEM16A Antibody consists of a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-ANO1/TMEM16A Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-ANO1/TMEM16A Antibody
  • HY-109077S
    Tigolaner-d4
    Tigolaner-d4 is deuterium labeled Tigolaner. Tigolaner (BAY-1272858) acts on γ-aminobutyric acid (GABA) and glutamate-gated chloride channels. Tigolaner has antiparasitic activity.
    Tigolaner-d<sub>4</sub>
Cat. No. Product Name / Synonyms Application Reactivity